Frailty, Comorbidity, and Functional Limitation Among Older Adults with Venous Leg Ulcers: A Cross-Sectional Study

Authors

  • Asmat Burhan Department Wound Care Unit, Podiatry Care Purwokerto, Central Java, Indonesia
  • Rahmad Effan Farhri Mahendra Department Wound Care Unit, Pontianak Care Center, West Kalimantan, Indonesia
  • Firman Rosadi Department Wound Ostomy Continents Care Unit, Griya Husada Kediri, East Java, Indonesia

Keywords:

activities of daily living, aged, comorbidity, frailty, leg ulcer, venous insufficiency

Abstract

Background: Venous leg ulcers in older adults are frequently accompanied by frailty, multimorbidity, and reduced physical independence, yet evidence on their combined relationship remains limited, particularly in Indonesian clinical settings.

Aim: To examine frailty, comorbidity, and functional limitation among older adults with venous leg ulcers

Approach: This cross-sectional study included 118 older adults with venous leg ulcers assessed between June 23 and August 1, 2022, using consecutive sampling. Eligible participants were aged 60 years or older with clinician-diagnosed venous leg ulcers. Frailty, comorbidity, and functional limitation were measured using validated instruments. Data were analyzed using multivariable linear regression

Results: A total of 118 patients completed the study. Results showed that the mean (SD) age was 69.8 (7.1) years, 71 participants (60.2%) were women, and the mean (SD) Barthel Index score was 72.4 (16.8). Frailty was present in 62 participants (52.5%). In the adjusted model, higher frailty score was associated with lower Barthel Index score (β = -2.85; 95% CI, -3.98 to -1.72; P < .001), as were higher comorbidity burden (β = -1.94; 95% CI, -3.29 to -0.59; P = .005) and greater pain intensity (β = -1.36; 95% CI, -2.28 to -0.44; P = .004)

Conclusions: Functional limitation was common among older adults with venous leg ulcers and was associated with frailty, comorbidity burden, and pain intensity

Implication for Clinical Practice: Routine venous leg ulcer assessment in older adults may benefit from brief screening for frailty, comorbidity, and pain to support risk identification, individualized care planning, and function-oriented wound management.

References

Barros, V. dos S., da Silva, J. M., Netto, J. J. M., de Oliveira, B. G. R. B., Andrade, M. S., & Peres, M. F. T. (2022). Barthel Index is a valid and reliable tool to measure the functional independence of cancer patients in palliative care. BMC Palliative Care, 21(1), 124. DOI: 10.1186/s12904-022-01017-z

Bjelkarøy, M. T., Benth, J. Š., Simonsen, T. B., Siddiqui, T. G., Cheng, S., Kristoffersen, E. S., & Lundqvist, C. (2024). Measuring pain intensity in older adults: Can the visual analogue scale and the numeric rating scale be used interchangeably? Progress in Neuro-Psychopharmacology & Biological Psychiatry, 130, 110925. DOI: 10.1016/j.pnpbp.2023.110925

Chu, L., Etkin, Y., Dowling, C., & Oropallo, A. (2025). Assessment and management of chronic venous, arterial, and diabetic wounds in older adults. Seminars in Vascular Surgery, 38(3), 281–290. DOI: 10.1053/j.semvascsurg.2025.06.007

Duluklu, B., Ivory, J., McElvaney, A., Bligh, A., Cahill-Collins, M., Gethin, G., Liew, A., & Sezgin, D. (2025). Frailty and comorbidity in older adults with and without diabetes and chronic leg ulcer: A cross-sectional study. International Wound Journal, 22(1), e70119. DOI: 10.1111/iwj.70119

Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009). Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses. Behavior Research Methods, 41(4), 1149–1160. DOI: 10.3758/BRM.41.4.1149

Folguera-Álvarez, C., Garrido-Elustondo, S., Rico-Blázquez, M., & Verdú-Soriano, J. (2022). Factors associated with the quality of life of patients with venous leg ulcers in primary care: Cross-sectional study. The International Journal of Lower Extremity Wounds, 21(4), 521–528. DOI: 10.1177/1534734620967562

Gethin, G., Vellinga, A., Tawfick, W., O’Loughlin, A., McIntosh, C., Mac Gilchrist, C., Murphy, L., Ejiugwo, M., O’Regan, M., Cameron, A., & Ivory, J. D. (2021). The profile of patients with venous leg ulcers: A systematic review and global perspective. Journal of Tissue Viability, 30(1), 78–88. DOI: 10.1016/j.jtv.2020.08.003

Graves, N., Ganesan, G., Tan, K. B., Goh, O. Q. M., Ho, J., Chong, T. T., Bishnoi, P., Carmody, D., Yuh, A. S., Ng, Y. Z., Lo, Z., Enming, Y., Aloweni, F. A. B., Zifei, W., & Harding, K. (2023). Chronic wounds in a multiethnic Asian population: A cost of illness study. BMJ Open, 13(9), e065692. DOI: 10.1136/bmjopen-2022-065692

Huang, E. Y. Z., Cheung, J., Liu, J. Y. W., Kwan, R. Y. C., & Lam, S. C. (2022). Groningen Frailty Indicator–Chinese (GFI-C) for pre-frailty and frailty assessment among older people living in communities: Psychometric properties and diagnostic accuracy. BMC Geriatrics, 22(1), 788. DOI: 10.1186/s12877-022-03437-1

Mayrovitz, H. N., Wong, S., & Mancuso, C. (2023). Venous, arterial, and neuropathic leg ulcers with emphasis on the geriatric population. Cureus, 15(4), e38123. DOI: 10.7759/cureus.38123

McDaniel, J. C., Kim, B., McGowan, D. R., & Tan, A. (2025). Factors associated with quality of life in patients with venous leg ulcers in a community setting: A cross-sectional study. Health Science Reports, 8(11), e71441. DOI: 10.1002/hsr2.71441

Nimmaanrat, S., Thepsuwan, A., Tipchatyotin, S., Junpee, A., & Phinkhian, S. (2024). Measuring pain intensity in older patients: A comparison of five scales. BMC Geriatrics, 24(1), 556. DOI: 10.1186/s12877-024-05127-6

Probst, S., Saini, C., Gschwind, G., Stefanelli, A., Bobbink, P., Pugliese, M.-T., Cekic, S., Pastor, D., & Gethin, G. (2023). Prevalence and incidence of venous leg ulcers: A systematic review and meta-analysis. International Wound Journal, 20(9), 3906–3921. DOI: 10.1111/iwj.14272

Puspita Sari, L. G. M., & Suryawati, N. (2023). Characteristics of lower extremity ulcers among patients treated at Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Bali. Journal of the Medical Sciences (Berkala Ilmu Kedokteran), 55(4).* DOI: 10.19106/JMedSci005504202302

Raffetto, J. D., Ligi, D., Maniscalco, R., Khalil, R. A., & Mannello, F. (2021). Why venous leg ulcers have difficulty healing: Overview on pathophysiology, clinical consequences, and treatment. Journal of Clinical Medicine, 10(1), 29. DOI: 10.3390/jcm10010029

Sato, R., Taniguchi, Y., Watanabe, Y., Nofuji, Y., & Murayama, H. (2026). Declines in activities in daily living of older adults with sarcopenia were associated with gait speed. Medicina, 62(2), 263. DOI: 10.3390/medicina62020263

Shin, D. W., & Han, K. (2025). The use of Charlson comorbidity index for observational studies using administrative data in Korea. Precision and Future Medicine, 9(1), 2–14. DOI: 10.23838/pfm.2024.00191

Siegling, M., Härtel, G., Ruegsegger, M., Weibel, L., Hug, K., Stoyanov, J., Sutter, F., & Läuchli, S. (2023). Mobility range, level of pain and sleep quality of patients with venous leg ulcers. International Wound Journal, 20(8), 3177–3184. DOI: 10.1111/iwj.14195

Zhang, J., Zhou, M., Liu, A., Ye, R., & Wang, Y. (2026). Determining optimal Barthel Index cutoff scores for predicting Longshi Scale grades across age groups in stroke patients. Frontiers in Aging, 7, 1701910. DOI: 10.3389/fragi.2026.1701910

Zorge, N. E., van Asten, S. A. V., Nikolaou, V., Ulrich, M., Hoeksema, H., Kannan, A., Papp, A., Probst, S., Stingl, D., Vuerstaek, J. D. D., & van Hecke, A. (2023). A prospective, multicentre study to assess frailty in elderly patients with leg ulcers (GERAS study). Journal of the European Academy of Dermatology and Venereology, 37(2), 428–435. DOI: 10.1111/jdv.18586

Downloads

Published

2026-03-27

How to Cite

Burhan, A., Mahendra, R. E. F., & Rosadi, F. (2026). Frailty, Comorbidity, and Functional Limitation Among Older Adults with Venous Leg Ulcers: A Cross-Sectional Study. Annals of Neurovascular Recovery, 1(1), 51–62. Retrieved from https://eism.web.id/index.php/anr/article/view/86